| Host: | Mammalian Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Active-Mouse ERBB3/HER3-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Gene Symbol: | Erbb3 |
| Gene ID: | 13867 |
| Uniprot ID: | ERBB3_MOUSE |
| Immunogen Region: | Ser20-His641 |
| Immunogen: | Mus musculus (Mouse) |
| Post Translational Modifications | Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. |
| Function | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it.ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. |
| Protein Name | Receptor Tyrosine-Protein Kinase Erbb-3Glial Growth Factor ReceptorProto-Oncogene-Like Protein C-Erbb-3 |
| Database Links | Reactome: R-MMU-1227986Reactome: -MMU-1236394Reactome: -MMU-1250196Reactome: -MMU-1257604Reactome: -MMU-1306955Reactome: -MMU-1358803Reactome: -MMU-1963642Reactome: -MMU-5673001Reactome: -MMU-6785631Reactome: -MMU-6811558Reactome: -MMU-8847993Reactome: -MMU-8863795 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Receptor Tyrosine-Protein Kinase Erbb-3 proteinGlial Growth Factor Receptor proteinProto-Oncogene-Like Protein C-Erbb-3 proteinErbb3 protein |
Information sourced from Uniprot.org