Mouse EGFR/ERBB1/HER1 protein (Recombinant) (C-His) (STJP015288)
SPECIFICATIONS
HostMammalian Cells
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Mouse EGFR/ERBB1/HER1-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | Egfr |
| Gene ID | 13649 |
| Uniprot ID | EGFR_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Met1-Ser647 |
Additional Info
| Function | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration. Plays a role in enhancing learning and memory performance. Plays a role in mammalian pain signaling (long-lasting hypersensitivity). |
| Protein Name | Epidermal Growth Factor Receptor |
| Database Links | Reactome: R-MMU-1227986Reactome: -MMU-1236394Reactome: -MMU-1250196Reactome: -MMU-1257604Reactome: -MMU-177929Reactome: -MMU-179812Reactome: -MMU-180292Reactome: -MMU-180336Reactome: -MMU-182971Reactome: -MMU-1963642Reactome: -MMU-212718Reactome: -MMU-2179392Reactome: -MMU-445144Reactome: -MMU-5673001Reactome: -MMU-6785631Reactome: -MMU-6811558Reactome: -MMU-8847993Reactome: -MMU-8856825Reactome: -MMU-8856828Reactome: -MMU-8857538Reactome: -MMU-8863795Reactome: -MMU-9009391Reactome: -MMU-9013507 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum MembraneGolgi Apparatus MembraneNucleus MembraneEndosomeEndosome MembraneNucleusIn Response To EgfTranslocated From The Cell Membrane To The Nucleus Via Golgi And ErEndocytosed Upon Activation By LigandColocalized With Gper1 In The Nucleus Of Estrogen Agonist-Induced Cancer-Associated Fibroblasts (Caf) |
| Alternative Protein Names | Epidermal Growth Factor Receptor proteinEgfr protein |
Information sourced from Uniprot.org