Mouse EFNB2 protein (Recombinant) (C-Fc-His) (STJP013930)

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STJP013930-100
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Short Description :Recombinant-Mouse EFNB2-C-Fc-His protein was developed from mammalian cells and has a target region of C-Fc-His. For use in research applications.
Applications:ELISA/WB
Host:Mammalian Cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a 0.22 Mu m filtered solution in 20mM PB, 150mM NaCl, pH 7.4.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:< 1 EU/µg as determined by LAL test.
Gene Symbol:Efnb2
Gene ID:13642
Uniprot ID:EFNB2_MOUSE
Immunogen:Mus musculus (Mouse)
Immunogen Region:Arg29-Glu227
Post Translational Modifications Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
Function Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
Protein Name Ephrin-B2
Elf-2
Eph-Related Receptor Tyrosine Kinase Ligand 5
Lerk-5
Htk Ligand
Htk-L
Database Links Reactome: R-MMU-2682334
Reactome: -MMU-3928662
Reactome: -MMU-3928664
Reactome: -MMU-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Adherens Junction
Alternative Protein Names Ephrin-B2 protein
Elf-2 protein
Eph-Related Receptor Tyrosine Kinase Ligand 5 protein
Lerk-5 protein
Htk Ligand protein
Htk-L protein
Efnb2 protein
Elf2 protein
Epl5 protein
Eplg5 protein
Htkl protein
Lerk5 protein

Information sourced from Uniprot.org

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