| Tissue Specificity | Expressed in inner and outer pillar cells of the organ of Corti (at protein level). Expressed on lateral floor plate cells, specifically on commissural axon segments that have passed through the floor plate. Expressed in cells of the retinal ganglion cell layer during retinal axon guidance to the optic disk. Expressed in myogenic progenitor cells. |
| Post Translational Modifications | Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. |
| Function | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. |
| Protein Name | Ephrin-B2Elf-2Eph-Related Receptor Tyrosine Kinase Ligand 5Lerk-5Htk LigandHtk-L |
| Database Links | Reactome: R-MMU-2682334Reactome: -MMU-3928662Reactome: -MMU-3928664Reactome: -MMU-3928665 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionAdherens Junction |
| Alternative ELISA Names | Ephrin-B2 ELISA kitElf-2 ELISA kitEph-Related Receptor Tyrosine Kinase Ligand 5 ELISA kitLerk-5 ELISA kitHtk Ligand ELISA kitHtk-L ELISA kitEfnb2 ELISA kitElf2 ELISA kitEpl5 ELISA kitEplg5 ELISA kitHtkl ELISA kitLerk5 ELISA kit |
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Information sourced from Uniprot.org
