| Post Translational Modifications | Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. Proteolytically processed. The ectodomain is cleaved, probably by a metalloprotease, to produce a membrane-tethered C-terminal fragment. This fragment is then further processed by the gamma-secretase complex to yield a soluble intracellular domain peptide which can translocate to the nucleus. The intracellular domain peptide is highly labile suggesting that it is targeted for degradation by the proteasome. |
| Function | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells. Shows high affinity for the receptor tyrosine kinase EPHB1/ELK. Can also bind EPHB2 and EPHB3. Binds to, and induces the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. |
| Protein Name | Ephrin-B1Cek5 Receptor LigandCek5-LEfl-3Elk LigandElk-LEph-Related Receptor Tyrosine Kinase Ligand 2Lerk-2Stimulated By Retinoic Acid Gene 1 Protein Cleaved Into - Ephrin-B1 C-Terminal FragmentEphrin-B1 Ctf - Ephrin-B1 Intracellular DomainEphrin-B1 Icd |
| Database Links | Reactome: R-MMU-2682334Reactome: -MMU-3928662Reactome: -MMU-3928664Reactome: -MMU-3928665 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftMay Recruit Grip1 And Grip2 To Membrane Raft DomainsEphrin-B1 C-Terminal Fragment: Cell MembraneEphrin-B1 Intracellular Domain: NucleusColocalizes With Zhx2 In The Nucleus |
| Alternative Protein Names | Ephrin-B1 proteinCek5 Receptor Ligand proteinCek5-L proteinEfl-3 proteinElk Ligand proteinElk-L proteinEph-Related Receptor Tyrosine Kinase Ligand 2 proteinLerk-2 proteinStimulated By Retinoic Acid Gene 1 Protein Cleaved Into - Ephrin-B1 C-Terminal Fragment proteinEphrin-B1 Ctf - Ephrin-B1 Intracellular Domain proteinEphrin-B1 Icd proteinEfnb1 proteinEpl2 proteinEplg2 proteinLerk2 proteinStra1 protein |
Information sourced from Uniprot.org
