| Tissue Specificity | Highest expression in the adult is in lung. Lower levels found in heart, kidney, brain and intestine. In the embryo, expressed in outer and inner pharyngeal arch surfaces. Also expressed in endothelium of dorsal aorta and arch arteries, and in epithelium of pharyngeal pouches. |
| Post Translational Modifications | |
| Function | Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Also binds the DEAR/FBXW7-AS1 receptor. Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments. NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2. |
| Protein Name | Endothelin-1Et-1Preproendothelin-1Ppet1 Cleaved Into - Big Endothelin-1 |
| Database Links | Reactome: R-MMU-375276Reactome: -MMU-416476 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Endothelin-1 ELISA kitEt-1 ELISA kitPreproendothelin-1 ELISA kitPpet1 Cleaved Into - Big Endothelin-1 ELISA kitEdn1 ELISA kit |
| output | |
Information sourced from Uniprot.org
