Mouse DNMT3B (DNA Methyltransferase 3B) Sandwich ELISA Kit Ready-To-Use Kit (STJE0014863)

Mouse DNMT3B (DNA Methyltransferase 3B) Sandwich ELISA Kit Ready-To-Use Kit (STJE0014863)

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STJE0014863
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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.047ng/mL
Detection Limit: 0.156-10ng/mL
Short Description : This DNMT3B Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Dnmt3b
Gene ID: 13436
Uniprot ID: DNM3B_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications Sumoylated. Citrullinated by PADI4.
Function Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells.
Protein Name Dna
Cytosine-5-Methyltransferase 3b
Dnmt3b
Dna Methyltransferase Mmuiiib
Dna Mtase Mmuiiib
M.mmuiiib
Database Links Reactome: R-MMU-212300
Reactome: -MMU-4655427
Cellular Localisation Nucleus
Accumulates In The Major Satellite Repeats At Pericentric Heterochromatin
Alternative ELISA Names Dna ELISA kit
Cytosine-5-Methyltransferase 3b ELISA kit
Dnmt3b ELISA kit
Dna Methyltransferase Mmuiiib ELISA kit
Dna Mtase Mmuiiib ELISA kit
M.mmuiiib ELISA kit
Dnmt3b ELISA kit
output

Information sourced from Uniprot.org

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