Mouse DLL4 protein (Recombinant) (C-6His) (STJP002880)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse DLL4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly27-Ala532) of mouse DLL4 (Accession #NP_062327.2) fused with and a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Mouse DLL4-C-6His protein was developed in hek293 cells using the region Gly27-Ala532. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | Dll4 |
| Gene ID | 54485 |
| Uniprot ID | DLL4_MOUSE |
| Immunogen | Recombinant Mouse DLL4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly27-Ala532) of mouse DLL4 (Accession #NP_062327.2) fused with and a 6×His tag at the C-terminus. |
| Immunogen Region | Gly27-Ala532 |
| Immunogen Sequence | GSGIFQLRLQEFVNQRGMLA NGQSCEPGCRTFFRICLKHF QATFSEGPCTFGNVSTPVLG TNSFVVRDKNSGSGRNPLQL PFNFTWPGTFSLNIQAWHTP GDDLRPETSPGNSLISQIII QGSLAVGKIWRTDEQNDTLT RLSYSYRVICSDNYYGESCS RLCKKRDDHFGHYECQPDGS LSCLPGWTGKYCDQPICLSG CHEQNGYCSKPDECICRPGW QGRLCNECIPHNGCRHGTC |
Additional Info
| Function | Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis.negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate. |
| Protein Name | Delta-Like Protein 4Drosophila Delta Homolog 4Delta4 |
| Database Links | Reactome: R-MMU-2979096Reactome: -MMU-9013507 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Delta-Like Protein 4 proteinDrosophila Delta Homolog 4 proteinDelta4 proteinDll4 protein |
Information sourced from Uniprot.org