| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.115ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description : | This DIO3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | Dio3 |
| Gene ID: | 107585 |
| Uniprot ID: | IOD3_MOUSE |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,3',5'-triiodothyronine (rT3), 3,5,3'-triiodothyronine (T3) to 3,3'-diiodothyronine (3,3'-T2), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine (3-T1), rT3 to 3',5'-diiodothyronine (3',5'-T2) and 3,3'-T2 to 3'-monoiodothyronine (3'-T1) via inner-ring deiodination (IRD). Catalyzes the deiodination of 3-T1 to L-thyronine (T0) via outer-ring deiodination (ORD). Catalyzes the tyrosyl ring deiodinations of 3,3',5,5'-tetraiodothyronamine, 3,3',5'-triiodothyronamine, 3,5,3'-triiodothyronamine, 3,5-diiodothyronamine, 3,3'-diiodothyronamine and 3-iodothyronamine. |
| Protein Name | Thyroxine 5-Deiodinase5diiiDioiiiType 3 DiType Iii Iodothyronine Deiodinase |
| Database Links | Reactome: R-MMU-350864 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinEndosome Membrane |
| Alternative ELISA Names | Thyroxine 5-Deiodinase ELISA kit5diii ELISA kitDioiii ELISA kitType 3 Di ELISA kitType Iii Iodothyronine Deiodinase ELISA kitDio3 ELISA kit |
| output |
Information sourced from Uniprot.org
