Mouse DCC protein (Recombinant) (N-His) (STJP009221)

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STJP009221
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse DCC-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Dcc
Gene ID: 13176
Uniprot ID: DCC_MOUSE
Immunogen Region: Ser39-Ser232
Immunogen: Mus musculus (Mouse)
Post Translational Modifications Ubiquitinated.mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Function Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
Protein Name Netrin Receptor Dcc
Tumor Suppressor Protein Dcc
Database Links Reactome: R-MMU-373752
Reactome: -MMU-418885
Reactome: -MMU-418889
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Netrin Receptor Dcc protein
Tumor Suppressor Protein Dcc protein
Dcc protein

Information sourced from Uniprot.org

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