| Function | Antagonist of the extracellular signaling protein NODAL, which is required for correct left-right patterning during embryonic development. Antagonist of BMP4 signaling. Antagonist of TGF-beta signaling. Independently of its role in left-right axis establishment, plays a role during heart development, possibly through the regulation of TGF-beta/Nodal signaling pathway. Displays anti-angiogenic activity by inhibiting endothelial sprouting, migration, and proliferation. Once internalized by endothelial cells, may alter their redox and glycolytic balance. |
| Protein Name | Dan Domain Family Member 5Cerberus-Like Protein 2Cerl-2 |
| Database Links | |
| Cellular Localisation | SecretedCirculating Dand5 May Be Uptaken By Endothelial Cells And Transported To Mitochondria |
| Alternative Protein Names | Dan Domain Family Member 5 proteinCerberus-Like Protein 2 proteinCerl-2 proteinDand5 proteinCerl2 proteinCoco proteinSp1 protein |
Information sourced from Uniprot.org