| Tissue Specificity | Expressed mainly in brain. Specifically expressin in cortical neurons. |
| Post Translational Modifications | Phosphorylated by FYN on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also found phosphorylated on Tyr-232 upon reelin induction. Also phosphorylated on Ser-524 independently of reelin signaling. Ubiquitinated by various cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes) following ligand-binding and phosphorylation, leading to its degradation. Ubiquitinated by the ECS(SOCS7) complex in the cortical plate of the developing cerebral cortex following ligand-binding and phosphorylation by FYN, leading to its degradation by the proteasome. Recognized by ZSWIM8 through a disorder targets misorder mechanism that eliminates misfolded DAB1 via ubiquitination and proteasomal degradation. |
| Function | Signaling adapter of the reelin-mediated signaling pathway, which regulates the migration and differentiation of postmitotic neurons during brain development. Mediates intracellular transduction of Reelin signaling following reelin (RELN)-binding to its receptor: acts by docking proteins through its phosphotyrosine residues and PID domain. |
| Protein Name | Disabled Homolog 1Mdab1 |
| Database Links | Reactome: R-MMU-8866376 |
| Cellular Localisation | Cytoplasm |
| Alternative ELISA Names | Disabled Homolog 1 ELISA kitMdab1 ELISA kitDab1 ELISA kit |
| output | |
Information sourced from Uniprot.org
