| Tissue Specificity | Low in kidney, adrenal gland, testes, brain, and ovary, moderate in heart, uterus, and skeletal muscle, highest in lung. |
| Post Translational Modifications | |
| Function | Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3. |
| Protein Name | Ccn Family Member 13ch61Cellular Communication Network Factor 1Cysteine-Rich Angiogenic Inducer 61Insulin-Like Growth Factor-Binding Protein 10Ibp-10Igf-Binding Protein 10Igfbp-10Protein Cyr61 |
| Database Links | Reactome: R-MMU-381426Reactome: -MMU-8957275 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Ccn Family Member 1 ELISA kit3ch61 ELISA kitCellular Communication Network Factor 1 ELISA kitCysteine-Rich Angiogenic Inducer 61 ELISA kitInsulin-Like Growth Factor-Binding Protein 10 ELISA kitIbp-10 ELISA kitIgf-Binding Protein 10 ELISA kitIgfbp-10 ELISA kitProtein Cyr61 ELISA kitCcn1 ELISA kitCyr61 ELISA kitIgfbp10 ELISA kit |
| output | |
Information sourced from Uniprot.org
