Mouse Cyclophilin 40/PPID protein (Recombinant) (His-Tag) (STJP019366)
SPECIFICATIONS
HostE.coli
ImmunogenMouse
General Information
| Short Description | Recombinant-Mouse Cyclophilin 40/PPID-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Enzyme Activity |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Specific activity is > 700nmol/min/mg, and is defined as the amount of enzyme that cleaves 1nmole of suc-AAPF-pNA per minute at 37C in Tris-HCl pH 8.0 using chymotrypsin |
Target Information
| Gene Symbol | Ppid |
| Gene ID | 67738 |
| Uniprot ID | PPID_MOUSE |
| Accession Number | NP_080628 |
| Immunogen | Mouse |
| Immunogen Region | 1-370aa |
| Immunogen Sequence |
Additional Info
| Function | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer.the function is independent of HSP90 but requires the chaperone activity region. Involved in regulation of UV radiation-induced apoptosis. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase DPpiase D40 Kda Peptidyl-Prolyl Cis-Trans IsomeraseCyclophilin-40Cyp-40Rotamase D |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusNucleolusNucleoplasm |
| Alternative Protein Names | Peptidyl-Prolyl Cis-Trans Isomerase D proteinPpiase D protein40 Kda Peptidyl-Prolyl Cis-Trans Isomerase proteinCyclophilin-40 proteinCyp-40 proteinRotamase D proteinPpid protein |
Information sourced from Uniprot.org