Recombinant Mouse CXCL4/PF-4 Protein 1/FSTL1 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 40-45kDa.

Mouse CXCL4/PF-4 protein (Recombinant) (N-His) (STJP003072)

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STJP003072
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Host: E.coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% Trehalose is added as protectant before lyophilisation.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: <0.01 EU/ug
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human CCL5 at 5 Mu g/mL (100 Mu L/well) can bind Mouse CXCL4 with a linear range of 10-252.6 ng/mL.
Gene Symbol: Pf4
Gene ID: 56744
Uniprot ID: PLF4_MOUSE
Immunogen Region: Val30-Ser105
Immunogen: Recombinant Mouse CXCL4/PF-4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val30-Ser105) of Mouse CXCL4/PF-4 (Accession #NP_064316.1) fused with a hFc at the C-terminus.
Immunogen Sequence: MATLKDQLIYNLLKEEQTPQ NKITVVGVGAVGMACAISIL MKDLADELALVDVIEDKLKG EMMDLQHGSLFLRTPKIVSG KDYNVTANSKLVIITAGARQ QEGESRLNLVQRNVNIFKFI IPNVVKYSPNCKLLIVSNPV DILTYVAWKISGFPKNRVIG SGCNLDSARFRYLMGERLGV HPLSCHGWVLGEHGDSSVPV WSGMNVAGVSLKTLHPDLGT DKDKEQWKEVHKQVVESAY
Function Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation. Acts via different functional receptors including CCR1, CXCR3A or CXCR3B. Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence. Chemotactic for neutrophils and monocytes via CCR1. Inhibits endothelial cell proliferation. In cooperation with toll-like receptor 8/TLR8, induces chromatin remodeling and activates inflammatory gene expression via the TBK1-IRF5 axis. In addition, induces myofibroblast differentiation and collagen synthesis in different precursor cells, including endothelial cells, by stimulating endothelial-to-mesenchymal transition. Interacts with thrombomodulin/THBD to enhance the activation of protein C and thus potentiates its anticoagulant activity.
Protein Name Platelet Factor 4
Pf-4
C-X-C Motif Chemokine 4
Database Links Reactome: R-MMU-114608
Reactome: -MMU-140875
Reactome: -MMU-202733
Reactome: -MMU-380108
Reactome: -MMU-418594
Cellular Localisation Secreted
Alternative Protein Names Platelet Factor 4 protein
Pf-4 protein
C-X-C Motif Chemokine 4 protein
Pf4 protein
Cxcl4 protein
Scyb4 protein

Information sourced from Uniprot.org

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