Mouse CXCL4/PF-4 protein (Recombinant) (C-His) (STJP003104)
SPECIFICATIONS
HostMouse
ConjugationUnconjugated
ImmunogenRecombinant Mouse CXCL4/PF-4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val30-Ser105) of Mouse CXCL4/PF-4 (Accession #NP_064316.1) fused with a His tag at the C-terminus.
General Information
| Short Description | Recombinant-Mouse CXCL4/PF-4-C-His protein was developed in mouse using the region Val30-Ser105. For use in research applications. |
| Host | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | Pf4 |
| Gene ID | 56744 |
| Uniprot ID | PLF4_MOUSE |
| Immunogen | Recombinant Mouse CXCL4/PF-4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val30-Ser105) of Mouse CXCL4/PF-4 (Accession #NP_064316.1) fused with a His tag at the C-terminus. |
| Immunogen Region | Val30-Ser105 |
| Immunogen Sequence | VTSAGPEESDGDLSCVCVKT ISSGIHLKHITSLEVIKAGR HCAVPQLIATLKNGRKICLD RQAPLYKKVIKKILES |
Additional Info
| Function | Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation. Acts via different functional receptors including CCR1, CXCR3A or CXCR3B. Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence. Chemotactic for neutrophils and monocytes via CCR1. Inhibits endothelial cell proliferation. In cooperation with toll-like receptor 8/TLR8, induces chromatin remodeling and activates inflammatory gene expression via the TBK1-IRF5 axis. In addition, induces myofibroblast differentiation and collagen synthesis in different precursor cells, including endothelial cells, by stimulating endothelial-to-mesenchymal transition. Interacts with thrombomodulin/THBD to enhance the activation of protein C and thus potentiates its anticoagulant activity. |
| Protein Name | Platelet Factor 4Pf-4C-X-C Motif Chemokine 4 |
| Database Links | Reactome: R-MMU-114608Reactome: -MMU-140875Reactome: -MMU-202733Reactome: -MMU-380108Reactome: -MMU-418594 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Platelet Factor 4 proteinPf-4 proteinC-X-C Motif Chemokine 4 proteinPf4 proteinCxcl4 proteinScyb4 protein |
Information sourced from Uniprot.org