Mouse CXCL12/SDF-1 protein (Recombinant) (Tag free) (STJP014878)

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STJP014878-100
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Short Description :Recombinant-Mouse CXCL12/SDF-1-Tag free protein was developed from e.coli and has a target region of Tag free. For use in research applications.
Applications:ELISA/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a 0.22 Mu m filtered solution in 25mM Tris-HCl, 150mM NaCl, pH 8.5.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:< 1 EU/µg as determined by LAL test.
Gene Symbol:Cxcl12
Gene ID:20315
Uniprot ID:SDF1_MOUSE
Immunogen:Mus musculus (Mouse)
Immunogen Region:Lys22-Lys89
Function Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development.required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells.
Protein Name Stromal Cell-Derived Factor 1
Sdf-1
12-O-Tetradecanoylphorbol 13-Acetate Repressed Protein 1
Tpar1
C-X-C Motif Chemokine 12
Pre-B Cell Growth-Stimulating Factor
Pbsf
Thymic Lymphoma Cell-Stimulating Factor
Tlsf
Database Links Reactome: R-MMU-376176
Reactome: -MMU-380108
Reactome: -MMU-418594
Cellular Localisation Secreted
Alternative Protein Names Stromal Cell-Derived Factor 1 protein
Sdf-1 protein
12-O-Tetradecanoylphorbol 13-Acetate Repressed Protein 1 protein
Tpar1 protein
C-X-C Motif Chemokine 12 protein
Pre-B Cell Growth-Stimulating Factor protein
Pbsf protein
Thymic Lymphoma Cell-Stimulating Factor protein
Tlsf protein
Cxcl12 protein
Sdf1 protein

Information sourced from Uniprot.org

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