Mouse CXCL12/SDF-1 protein (Recombinant-Active) (C-hFc-His) (STJP011988)

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STJP011988-100
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Mouse CXCL12/SDF-1-C-hFc-His protein was developed from e. coli and has a target region of C-hFc-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: Cxcl12
Gene ID: 20315
Uniprot ID: SDF1_MOUSE
Immunogen Region: Lys22-Lys89
Immunogen: Mus musculus (Mouse)
Function Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development.required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells.
Protein Name Stromal Cell-Derived Factor 1
Sdf-1
12-O-Tetradecanoylphorbol 13-Acetate Repressed Protein 1
Tpar1
C-X-C Motif Chemokine 12
Pre-B Cell Growth-Stimulating Factor
Pbsf
Thymic Lymphoma Cell-Stimulating Factor
Tlsf
Database Links Reactome: R-MMU-376176
Reactome: -MMU-380108
Reactome: -MMU-418594
Cellular Localisation Secreted
Alternative Protein Names Stromal Cell-Derived Factor 1 protein
Sdf-1 protein
12-O-Tetradecanoylphorbol 13-Acetate Repressed Protein 1 protein
Tpar1 protein
C-X-C Motif Chemokine 12 protein
Pre-B Cell Growth-Stimulating Factor protein
Pbsf protein
Thymic Lymphoma Cell-Stimulating Factor protein
Tlsf protein
Cxcl12 protein
Sdf1 protein

Information sourced from Uniprot.org

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