• Mouse CTLA-4/CD152 protein (Recombinant) (C-His) (STJP001319)
  • Mouse CTLA-4/CD152 protein (Recombinant) (C-His) (STJP001319)
  • Mouse CTLA-4/CD152 protein (Recombinant) (C-His) (STJP001319)
  • Mouse CTLA-4/CD152 protein (Recombinant) (C-His) (STJP001319)

Mouse CTLA-4/CD152 protein (Recombinant) (C-His) (STJP001319)

SKU:
STJP001319

£59.50 - £156.50
Current Stock:
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse CTLA-4/CD152-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Mouse CTLA-4/CD152 at 2 Mu g/mL (100 Mu L/well) can bind Mouse B7-2/CD86 with a linear range of 0.1-51.8 ng/mL.
Gene Symbol: Ctla4
Gene ID: 12477
Uniprot ID: CTLA4_MOUSE
Immunogen: Recombinant Mouse CTLA-4/CD152 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu36-Asp161) of Mouse CTLA4 (Accession #NP_033973.2) fused with an 6×His tag at the C-terminus.
Post Translational Modifications N-glycosylation is important for dimerization. Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.
Function Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Protein Name Cytotoxic T-Lymphocyte Protein 4
Cytotoxic T-Lymphocyte-Associated Antigen 4
Ctla-4
Cd Antigen Cd152
Database Links Reactome: R-MMU-389513
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Exists Primarily An Intracellular Antigen Whose Surface Expression Is Tightly Regulated By Restricted Trafficking To The Cell Surface And Rapid Internalization
Alternative Protein Names Cytotoxic T-Lymphocyte Protein 4 protein
Cytotoxic T-Lymphocyte-Associated Antigen 4 protein
Ctla-4 protein
Cd Antigen Cd152 protein
Ctla4 protein
Cd152 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance