| Post Translational Modifications | Reversibly palmitoylated. Palmitoylation at Cys-79 by DHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization. Increased phosphorylation during mitosis prevents binding to microtubules. |
| Function | High-affinity epithelial cell surface receptor for APF. Mediates the anchoring of the endoplasmic reticulum to microtubules. |
| Protein Name | Cytoskeleton-Associated Protein 463-Kda Cytoskeleton-Linking Membrane ProteinClimp-63P63 |
| Database Links | Reactome: R-MMU-381426Reactome: -MMU-5683826Reactome: -MMU-6798695Reactome: -MMU-8957275Reactome: -MMU-9696264Reactome: -MMU-9696270 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinCell MembraneCytoplasmCytoskeletonPerinuclear RegionTranslocates To The Perinuclear Region Upon Apf-Stimulation |
| Alternative Protein Names | Cytoskeleton-Associated Protein 4 protein63-Kda Cytoskeleton-Linking Membrane Protein proteinClimp-63 proteinP63 proteinCkap4 protein |
Information sourced from Uniprot.org