Post Translational Modifications | N-glycosylated. |
Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan. Can also catalyze the sulfation of the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen. |
Protein Name | Carbohydrate Sulfotransferase 3Chondroitin 6-O-Sulfotransferase 1C6st-1Chondroitin 6-SulfotransferaseC6stGalactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 0Gst-0 |
Database Links | Reactome: R-MMU-2022870 |
Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
Alternative Protein Names | Carbohydrate Sulfotransferase 3 proteinChondroitin 6-O-Sulfotransferase 1 proteinC6st-1 proteinChondroitin 6-Sulfotransferase proteinC6st proteinGalactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 0 proteinGst-0 proteinChst3 proteinC6st proteinGst0 protein |
Information sourced from Uniprot.org