| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. |
| Protein Name | Cyclin-Dependent Kinase 8Cell Division Protein Kinase 8Mediator Complex Subunit Cdk8Mediator Of Rna Polymerase Ii Transcription Subunit Cdk8 |
| Database Links | Reactome: R-MMU-2173796 |
| Cellular Localisation | Nucleus |
| Alternative ELISA Names | Cyclin-Dependent Kinase 8 ELISA kitCell Division Protein Kinase 8 ELISA kitMediator Complex Subunit Cdk8 ELISA kitMediator Of Rna Polymerase Ii Transcription Subunit Cdk8 ELISA kitCdk8 ELISA kit |
| output | |
Information sourced from Uniprot.org
