| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.065ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description : | This CDH2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates, cell lysates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | Cdh2 |
| Gene ID: | 12558 |
| Uniprot ID: | CADH2_MOUSE |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Expressed in cardiac muscle (at protein level). |
| Post Translational Modifications | Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa N-terminal soluble fragment and a 45 kDa membrane-bound C-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence. May be phosphorylated by OBSCN. O-glycosylated on Ser and Thr residues. |
| Function | Calcium-dependent cell adhesion protein.preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells. Required for proper neurite branching. Required for pre- and postsynaptic organization. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. |
| Protein Name | Cadherin-2 Neural Cadherin N-Cadherin Cd Antigen Cd325 |
| Database Links | Reactome: R-MMU-381426 Reactome: -MMU-418990 Reactome: -MMU-525793 Reactome: -MMU-8957275 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Sarcolemma Cell Junction Adherens Junction Desmosome Cell Surface Colocalizes With Tmem65 At The Intercalated Disk In Cardiomyocytes Colocalizes With Obscn At The Intercalated Disk And Sarcolemma In Cardiomyocytes |
| Alternative ELISA Names | Cadherin-2 ELISA kit Neural Cadherin ELISA kit N-Cadherin ELISA kit Cd Antigen Cd325 ELISA kit Cdh2 ELISA kit |
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Information sourced from Uniprot.org