Mouse CD85k/LILRB4/ILT3 protein (Recombinant) (C-Fc) (STJP013984)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Mouse CD85k/LILRB4/ILT3-C-Fc protein was developed from mammalian cells and has a target region of C-Fc. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in 50mM Tris-HCl, 100mM Glycine, pH 7.5. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | Lilrb4a |
| Gene ID | 14728 |
| Uniprot ID | LRB4A_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Gly24-Lys238 |
Additional Info
| Post Translational Modifications | Tyrosine phosphorylated. |
| Function | Inhibitory receptor involved in the down-regulation of the immune response. Receptor for FN1. Receptor for integrin ITGAV/ITGB3. Inhibits IgE-mediated mast cell activation, at least in part through interaction with ITGAV/ITGB3. Also inhibits KITLG/SCF-mediated mast cell activation. Through interaction with ITGAV/ITGB3, inhibits antibody production by memory and marginal zone B cells, probably by suppressing their differentiation into plasma cells. Inhibits IFNG production by CD8 T cells, CD4 T cells and natural killer cells. Inhibits antigen presentation by dendritic cells to T cells, preventing T cell activation. Inhibits lipopolysaccharide-mediated neutrophil-dependent vascular injury. Suppresses the allergic inflammatory response by inhibiting infiltration of neutrophils and eosinophils and preventing mast cell degranulation. Inhibits lysis by natural killer cells. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4aMast Cell Surface Glycoprotein Gp49bCd Antigen Cd85k |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4a proteinMast Cell Surface Glycoprotein Gp49b proteinCd Antigen Cd85k proteinLilrb4a proteinGp49b protein |
Information sourced from Uniprot.org