Mouse CD85k/LILRB4/ILT3 protein (Recombinant) (C-Fc) (STJP013984)

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STJP013984-100
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Host: Mammalian Cells
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse CD85k/LILRB4/ILT3-C-Fc protein was developed from mammalian cells and has a target region of C-Fc. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilized from a 0.22 Mu m filtered solution in 50mM Tris-HCl, 100mM Glycine, pH 7.5.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: Lilrb4a
Gene ID: 14728
Uniprot ID: LRB4A_MOUSE
Immunogen Region: Gly24-Lys238
Immunogen: Mus musculus (Mouse)
Post Translational Modifications Tyrosine phosphorylated.
Function Inhibitory receptor involved in the down-regulation of the immune response. Receptor for FN1. Receptor for integrin ITGAV/ITGB3. Inhibits IgE-mediated mast cell activation, at least in part through interaction with ITGAV/ITGB3. Also inhibits KITLG/SCF-mediated mast cell activation. Through interaction with ITGAV/ITGB3, inhibits antibody production by memory and marginal zone B cells, probably by suppressing their differentiation into plasma cells. Inhibits IFNG production by CD8 T cells, CD4 T cells and natural killer cells. Inhibits antigen presentation by dendritic cells to T cells, preventing T cell activation. Inhibits lipopolysaccharide-mediated neutrophil-dependent vascular injury. Suppresses the allergic inflammatory response by inhibiting infiltration of neutrophils and eosinophils and preventing mast cell degranulation. Inhibits lysis by natural killer cells.
Protein Name Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4a
Mast Cell Surface Glycoprotein Gp49b
Cd Antigen Cd85k
Database Links
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4a protein
Mast Cell Surface Glycoprotein Gp49b protein
Cd Antigen Cd85k protein
Lilrb4a protein
Gp49b protein

Information sourced from Uniprot.org

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