Mouse CD83 protein (Recombinant) (C-His) (STJP002780)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse CD83 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met22-Ala134) of mouse CD83 (Accession #NP_033986.1) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Mouse CD83-C-His protein was developed in hek293 cells using the region Met22-Ala134. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of 20 mM tris, 200 mM Nacl, pH 8.0 |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <1 EU/Mu g |
Target Information
| Gene Symbol | Cd83 |
| Gene ID | 12522 |
| Uniprot ID | CD83_MOUSE |
| Immunogen | Recombinant Mouse CD83 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met22-Ala134) of mouse CD83 (Accession #NP_033986.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Met22-Ala134 |
| Immunogen Sequence | MREVTVACSETADLPCTAPW DPQLSYAVSWAKVSESGTES VELPESKQNSSFEAPRRRAY SLTIQNTTICSSGTYRCALQ ELGGQRNLSGTVVLKVTGCP KEATESTFRKYRA |
Additional Info
| Function | Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHC II trafficking MARCHF8. Also inhibits MARCHF1 association with MHC II and ubiquitination of MHCII. In addition, acts as an important modulator of protective responses against acute infections. |
| Protein Name | Cd83 AntigenMcd83Cd Antigen Cd83 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Cd83 Antigen proteinMcd83 proteinCd Antigen Cd83 proteinCd83 protein |
Information sourced from Uniprot.org