Mouse CD55 protein (Recombinant) (C-His) (STJP020384)

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STJP020384
£96.50 - £282.50
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Host:HEK293 cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Formulation:Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4).
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:< 0.1 EU/Mu g of the protein by LAL method.
Gene Symbol:Cd55
Gene ID:13136
Uniprot ID:DAF1_MOUSE
Immunogen:Recombinant Mouse CD55 Protein is produced by HEK293 cells system. The target protein is expressed with sequence (Asp35-Gly362) of Mouse CD55 (Accession #NP_034146.2) fused with His tag at the C-Terminus.
Immunogen Region:Asp35-Gly362
Immunogen Sequence:DCGPPPDIPNARPILGRHSK FAEQSKVAYSCNNGFKQVPD KSNIVVCLENGQWSSHETFC EKSCVAPERLSFASLKKEYL NMNFFPVGTIVEYECRPGFR KQPPLPGKATCLEDLVWSPV AQFCKKKSCPNPKDLDNGHI NIPTGILFGSEINFSCNPGY RLVGVSSTFCSVTGNTVDWD DEFPVCTEIHCPEPPKINNG IMRGESDSYTYSQVVTYSCD KGFILVGNASIYCTVSKSD
Tissue Specificity Brain, secretory epithelia, skeletal muscle, liver, testes, thymus, spleen and lymph node.
Function This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage.
Protein Name Complement Decay-Accelerating Factor - Gpi-Anchored
Daf-Gpi
Cd Antigen Cd55
Database Links Reactome: R-MMU-373080
Reactome: -MMU-6798695
Reactome: -MMU-6807878
Reactome: -MMU-977606
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Alternative Protein Names Complement Decay-Accelerating Factor - Gpi-Anchored protein
Daf-Gpi protein
Cd Antigen Cd55 protein
Cd55 protein
Cd55a protein
Daf protein
Daf1 protein

Information sourced from Uniprot.org

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