| Host: |
HEK293 |
| Note: |
STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse CD48-protein was developed from hek293. For use in research applications. |
| Conjugation: |
Unconjugated |
| Formulation: |
0.2 Mu m filtered PBS solution, pH7.2. |
| Storage Instruction: |
Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin: |
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Immunoreactivity: |
The activity was tested by immobilized recombinant mouse CD48 (10ug/ml) ability to bind recombinant CD2 with a linear range of 20-100 ng/ml. NA |
| Gene Symbol: |
Cd48 |
| Gene ID: |
12506 |
| Uniprot ID: |
CD48_MOUSE |
| Immunogen Region: |
ECD |
| Immunogen: |
Optimized DNA sequence encoding extracellular domain of Mouse CD48including a C-terminal 6His tag was expressed in HEK293 cells. NA |
| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. |
| Protein Name | Cd48 AntigenBcm1 Surface AntigenBlast-1Hm48-1Mrc Ox-45 Surface AntigenSlam Family Member 2Slamf2Signaling Lymphocytic Activation Molecule 2Sgp-60Cd Antigen Cd48 |
| Database Links | Reactome: R-MMU-202733 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftSecreted |
| Alternative Protein Names | Cd48 Antigen proteinBcm1 Surface Antigen proteinBlast-1 proteinHm48-1 proteinMrc Ox-45 Surface Antigen proteinSlam Family Member 2 proteinSlamf2 proteinSignaling Lymphocytic Activation Molecule 2 proteinSgp-60 proteinCd Antigen Cd48 proteinCd48 proteinBcm-1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
