Mouse CD45/PTPRC protein (Recombinant) (N-His) (STJP011034)

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STJP011034
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse CD45/PTPRC-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Ptprc
Gene ID: 19264
Uniprot ID: PTPRC_MOUSE
Immunogen Region: Thr202-Phe563
Immunogen: Mus musculus (Mouse)
Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.
Protein Name Receptor-Type Tyrosine-Protein Phosphatase C
Leukocyte Common Antigen
L-Ca
Lymphocyte Antigen 5
Ly-5
T200
Cd Antigen Cd45
Database Links Reactome: R-MMU-202427
Reactome: -MMU-416700
Reactome: -MMU-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
Synapse
Colocalized With Dpp4 In Membrane Rafts
Alternative Protein Names Receptor-Type Tyrosine-Protein Phosphatase C protein
Leukocyte Common Antigen protein
L-Ca protein
Lymphocyte Antigen 5 protein
Ly-5 protein
T200 protein
Cd Antigen Cd45 protein
Ptprc protein
Ly-5 protein

Information sourced from Uniprot.org

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