| Post Translational Modifications | Phosphorylated on tyrosine residues.modestly increased after TCR/CD28 stimulation. Can be phosphorylated in the cytoplasmic domain by FYN. Phosphorylation at Tyr-256 is increased by stimulation with ligand LGALS9. N-glycosylated. |
| Function | Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits. In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN. Expressed on Treg cells can inhibit Th17 cell responses. Receptor for LGALS9. Binding to LGALS9 is believed to result in suppression of T-cell responses.the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth. However, the function as receptor for LGALS9 has been challenged. Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes. Receptor for phosphatidylserine (PtSer).PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes. Can enhance mast cell production of Th2 cytokines Il-4, IL-6 and IL-13. Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9. In contrast, shown to suppress NK cell-mediated cytotoxicity. Negatively regulates NK cell function in LPS-induced endotoxic shock. |
| Protein Name | Hepatitis A Virus Cellular Receptor 2 HomologHavcr-2T-Cell Immunoglobulin And Mucin Domain-Containing Protein 3Timd-3T-Cell Immunoglobulin Mucin Receptor 3Tim-3T-Cell Membrane Protein 3Cd Antigen Cd366 |
| Database Links | |
| Cellular Localisation | Isoform 1: MembraneSingle-Pass Type I Membrane ProteinCell JunctionLocalizes To The Immunological Synapse Between Cd8+ T-Cells And Target CellsIsoform 2: Secreted |
| Alternative Protein Names | Hepatitis A Virus Cellular Receptor 2 Homolog proteinHavcr-2 proteinT-Cell Immunoglobulin And Mucin Domain-Containing Protein 3 proteinTimd-3 proteinT-Cell Immunoglobulin Mucin Receptor 3 proteinTim-3 proteinT-Cell Membrane Protein 3 proteinCd Antigen Cd366 proteinHavcr2 proteinTim3 proteinTimd3 protein |
Information sourced from Uniprot.org
