| Post Translational Modifications | The expression in Sertoli cells is regulated by TGFB3 through ubiquitin-mediated proteasomal degradation. |
| Function | Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium. Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1. Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (Probable). Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons. During myogenesis, it is involved in myocyte fusion. May also play a role in angiogenesis. |
| Protein Name | Junctional Adhesion Molecule BJam-BJunctional Adhesion Molecule 2Jam-2Vascular Endothelial Junction-Associated MoleculeVe-JamCd Antigen Cd322 |
| Database Links | Reactome: R-MMU-202733Reactome: -MMU-216083 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionTight JunctionLocalized At Tight Junctions Of Both EpithelialEndothelial Cells And Sertoli CellsSpecifically Localized Within The Somatodendritic Compartment Of Neurons And Excluded From The Axon |
| Alternative Protein Names | Junctional Adhesion Molecule B proteinJam-B proteinJunctional Adhesion Molecule 2 proteinJam-2 proteinVascular Endothelial Junction-Associated Molecule proteinVe-Jam proteinCd Antigen Cd322 proteinJam2 proteinVejam protein |
Information sourced from Uniprot.org
