Mouse CD32/FcRII/Ly-17 protein (Recombinant) (N-His) (STJP009105)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Mouse CD32/FcRII/Ly-17-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | Fcgr2 |
| Gene ID | 14130 |
| Uniprot ID | FCGR2_MOUSE |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys35-Gly202 |
Additional Info
| Post Translational Modifications | Glycosylated. When coaggregated to BCR, isoform IIB1 and isoform IIB1' become tyrosine phosphorylated and bind to the SH2 domains of the protein tyrosine phosphatase PTPC1. Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK. |
| Function | Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells. Isoform IIB1 and isoform IIB1' form caps but fail to mediate endocytosis or phagocytosis. Isoform IIB2 can mediate the endocytosis of soluble immune complexes via clathrin-coated pits. Isoform IIB1 and isoform IIB2 can down-regulate B-cell, T-cell, and mast cell activation when coaggregated to B-cell receptors for AG (BCR), T-cell receptors for AG (TCR), and Fc receptors, respectively. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor IiFc Gamma Receptor IibFc-Gamma RiiFc-Gamma-RiibFcriiIgg Fc Receptor Ii BetaLymphocyte Antigen 17Ly-17Cd Antigen Cd32 |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-2029481Reactome: -MMU-2029482Reactome: -MMU-2029485Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform Iib1: CytoplasmCytoskeletonBinds The Cytoskeleton And Is Not Localized In Endocytotic PitsIsoform Iib3: SecretedReleased As A Soluble Molecule |
| Alternative Protein Names | Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii proteinFc Gamma Receptor Iib proteinFc-Gamma Rii proteinFc-Gamma-Riib proteinFcrii proteinIgg Fc Receptor Ii Beta proteinLymphocyte Antigen 17 proteinLy-17 proteinCd Antigen Cd32 proteinFcgr2 proteinFcgr2b proteinLy-17 protein |
Information sourced from Uniprot.org