Mouse CD304/NRP1 protein (Recombinant-Active) (C-His) (STJP011725)

Name: Mouse CD304/NRP1 protein (Recombinant-Active) (C-His) (STJP011725)
SKU: STJP011725-100
Price: 604.2 EUR
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostMammalian Cells

ConjugationUnconjugated

ImmunogenMus musculus (Mouse)

STJP011725-100

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Short Description	Recombinant-Active-Mouse CD304/NRP1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	<0.1 EU/Mu g of the protein by the LAL method.
Immunoreactivity	Measured by its binding ability in a functional ELISA. Immobilised recombinant Mouse CD304/NRP1 can bind recombinant human VEGF165 with an apparent KD <1 nM.

Function	Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR.
Protein Name	Neuropilin-1 A5 Protein Cd Antigen Cd304
Database Links	Reactome: R-MMU-194306 Reactome: -MMU-399954 Reactome: -MMU-399955 Reactome: -MMU-399956 Reactome: -MMU-445144
Cellular Localisation	Mitochondrion Membrane Single-Pass Type I Membrane Protein Cell Membrane Cytoplasm
Alternative Protein Names	Neuropilin-1 protein A5 Protein protein Cd Antigen Cd304 protein Nrp1 protein Nrp protein

Information sourced from Uniprot.org