Mouse CD304/NRP1 protein (Recombinant-Active) (C-His) (STJP011725)

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STJP011725-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Mouse CD304/NRP1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: Nrp1
Gene ID: 18186
Uniprot ID: NRP1_MOUSE
Immunogen Region: Phe22-Pro856
Immunogen: Mus musculus (Mouse)
Function Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR.
Protein Name Neuropilin-1
A5 Protein
Cd Antigen Cd304
Database Links Reactome: R-MMU-194306
Reactome: -MMU-399954
Reactome: -MMU-399955
Reactome: -MMU-399956
Reactome: -MMU-445144
Cellular Localisation Mitochondrion Membrane
Single-Pass Type I Membrane Protein
Cell Membrane
Cytoplasm
Alternative Protein Names Neuropilin-1 protein
A5 Protein protein
Cd Antigen Cd304 protein
Nrp1 protein
Nrp protein

Information sourced from Uniprot.org

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