| Post Translational Modifications | Phosphorylated on tyrosine. |
| Function | Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition.recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide which acts as a ligand. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement. (Microbial infection) Acts as a functional receptor for murine norovirus (MNV). Mediates binding to the cell surface and is both necessary and sufficient for viral entry and replication. This interaction requires Mg(2+) and Ca(2+) and is enhanced by bile acids. Primary determinant of MNV species tropism and is sufficient to render cells permissive to infection by MNV. Can render nonmurine mammalian cells susceptible to MNV infection. |
| Protein Name | Cmrf35-Like Molecule 1Clm-1Cd300 Antigen-Like Family Member FLeukocyte Mono-Ig-Like Receptor 3Myeloid-Associated Immunoglobulin-Like Receptor 5Mair-5Mair-VCd Antigen Cd300f |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Cmrf35-Like Molecule 1 proteinClm-1 proteinCd300 Antigen-Like Family Member F proteinLeukocyte Mono-Ig-Like Receptor 3 proteinMyeloid-Associated Immunoglobulin-Like Receptor 5 proteinMair-5 proteinMair-V proteinCd Antigen Cd300f proteinCd300lf proteinClm1 proteinLmir3 protein |
Information sourced from Uniprot.org
