Mouse CD27 protein (Recombinant) (C-Fc) (STJP015515)

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STJP015515
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Short Description :Recombinant-Mouse CD27-C-Fc protein was developed from mammalian cells for the region C-Fc. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:Mammalian Cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for further information.
Gene Symbol:Cd27
Gene ID:21940
Uniprot ID:CD27_MOUSE
Immunogen:Mus musculus (Mouse)
Immunogen Region:Met1-Arg182
Post Translational Modifications Phosphorylated. N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
Function Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue.
Protein Name Cd27 Antigen
Cd27l Receptor
T-Cell Activation Antigen Cd27
Tumor Necrosis Factor Receptor Superfamily Member 7
Cd Antigen Cd27
Database Links Reactome: R-MMU-5669034
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Cd27 Antigen protein
Cd27l Receptor protein
T-Cell Activation Antigen Cd27 protein
Tumor Necrosis Factor Receptor Superfamily Member 7 protein
Cd Antigen Cd27 protein
Cd27 protein
Tnfrsf7 protein

Information sourced from Uniprot.org

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