| Short Description : | Recombinant-Active-Mouse CD258/TNFSF14/LIGHT-N-His protein was developed from mammalian cells and has a target region of N-His. For use in research applications. |
| Applications: | ELISA/WB |
| Host: | Mammalian Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity: | Measured in a cytotoxicity assay using human colon adenocarcinoma cells (HT‑29). The ED50 for this effect is for this effect is less than 5 µg/mL in the presence of a cross-linking antibody, Anti-His mAb and recombinant human IFN-gamma. |
| Gene Symbol: | Tnfsf14 |
| Gene ID: | 50930 |
| Uniprot ID: | TNF14_MOUSE |
| Immunogen: | Mus musculus (Mouse) |
| Immunogen Region: | Asp72-Val239 |
| Function | Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB and stimulates the proliferation of T-cells. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 14Cd Antigen Cd258 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 14 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 14 - Soluble Form |
| Database Links | Reactome: R-MMU-5668541Reactome: -MMU-5676594 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinTumor Necrosis Factor Ligand Superfamily Member 14Soluble Form: Secreted |
| Alternative Protein Names | Tumor Necrosis Factor Ligand Superfamily Member 14 proteinCd Antigen Cd258 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 14 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 14 - Soluble Form proteinTnfsf14 proteinLight protein |
Information sourced from Uniprot.org
