Mouse CD248 protein (Recombinant) (N-His-SUMO) (STJP008726)

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STJP008726
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse CD248-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Cd248
Gene ID: 70445
Uniprot ID: CD248_MOUSE
Immunogen Region: Val19-Cys156
Immunogen: Mus musculus (Mouse)
Post Translational Modifications O-glycosylated by sialylated oligosaccharides. May be N-glycosylated.
Function Cell surface glycoprotein involved in various biological processes including angiogenesis, immune response modulation, and tissue remodeling and repair. Participates in pericyte proliferation through positive modulation of the PDGF receptor signaling pathway. Acts as a scaffold for factor X, triggering allosteric changes and the spatial re-alignment of factor X with the TF-factor VIIa complex, thereby enhancing coagulation activation. Modulates the insulin signaling pathway by interacting with insulin receptor/INSR and by diminishing its capacity to be autophosphorylated in response to insulin. Also regulates LPS-induced inflammatory responses in macrophages by favoring production of proinflammatory cytokines.
Protein Name Endosialin
Tumor Endothelial Marker 1
Cd Antigen Cd248
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Endosialin protein
Tumor Endothelial Marker 1 protein
Cd Antigen Cd248 protein
Cd248 protein
Tem1 protein

Information sourced from Uniprot.org

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