Function | Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells. On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway. |
Protein Name | Low Affinity Immunoglobulin Epsilon Fc ReceptorFc-Epsilon-RiiLymphocyte Ige ReceptorCd Antigen Cd23 |
Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinLipid-AnchorSecreted |
Alternative Protein Names | Low Affinity Immunoglobulin Epsilon Fc Receptor proteinFc-Epsilon-Rii proteinLymphocyte Ige Receptor proteinCd Antigen Cd23 proteinFcer2 proteinFcer2a protein |
Information sourced from Uniprot.org