Mouse CD224/GGT1 protein (Recombinant) (N-His) (STJP011041)

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STJP011041
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse CD224/GGT1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Ggt1
Gene ID: 14598
Uniprot ID: GGT1_MOUSE
Immunogen Region: Arg39-Tyr568
Immunogen: Mus musculus (Mouse)
Function Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4. Indirectly regulates multiple aspects of skeletal biology.
Protein Name Glutathione Hydrolase 1 Proenzyme
Gamma-Glutamyltransferase 1
Gamma-Glutamyltranspeptidase 1
Ggt 1
Leukotriene-C4 Hydrolase
Cd Antigen Cd224 Cleaved Into - Glutathione Hydrolase 1 Heavy Chain - Glutathione Hydrolase 1 Light Chain
Database Links Reactome: R-MMU-174403
Reactome: -MMU-2142691
Reactome: -MMU-5423646
Reactome: -MMU-9753281
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names Glutathione Hydrolase 1 Proenzyme protein
Gamma-Glutamyltransferase 1 protein
Gamma-Glutamyltranspeptidase 1 protein
Ggt 1 protein
Leukotriene-C4 Hydrolase protein
Cd Antigen Cd224 Cleaved Into - Glutathione Hydrolase 1 Heavy Chain - Glutathione Hydrolase 1 Light Chain protein
Ggt1 protein
Ggt protein
Ggtp protein

Information sourced from Uniprot.org

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