Mouse CD167b/DDR2 protein (Recombinant) (C-His) (STJP013972)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Mouse CD167b/DDR2-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | Ddr2 |
| Gene ID | 18214 |
| Uniprot ID | DDR2_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Gln24-Arg399 |
Additional Info
| Post Translational Modifications | N-glycosylated. Tyrosine phosphorylated in response to collagen binding. Phosphorylated by SRC.this is required for activation and subsequent autophosphorylation on additional tyrosine residues. |
| Function | Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. |
| Protein Name | Discoidin Domain-Containing Receptor 2Discoidin Domain Receptor 2Cd167 Antigen-Like Family Member BNeurotrophic Tyrosine Kinase - Receptor-Related 3Receptor Protein-Tyrosine Kinase TktTyrosine-Protein Kinase Tyro10Cd Antigen Cd167b |
| Database Links | Reactome: R-MMU-3000171 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Discoidin Domain-Containing Receptor 2 proteinDiscoidin Domain Receptor 2 proteinCd167 Antigen-Like Family Member B proteinNeurotrophic Tyrosine Kinase - Receptor-Related 3 proteinReceptor Protein-Tyrosine Kinase Tkt proteinTyrosine-Protein Kinase Tyro10 proteinCd Antigen Cd167b proteinDdr2 proteinNtrkr3 proteinTkt proteinTyro10 protein |
Information sourced from Uniprot.org