Mouse CD167b/DDR2 protein (Recombinant) (C-His) (STJP013972)

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STJP013972-100
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Host: Mammalian Cells
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse CD167b/DDR2-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: Ddr2
Gene ID: 18214
Uniprot ID: DDR2_MOUSE
Immunogen Region: Gln24-Arg399
Immunogen: Mus musculus (Mouse)
Post Translational Modifications N-glycosylated. Tyrosine phosphorylated in response to collagen binding. Phosphorylated by SRC.this is required for activation and subsequent autophosphorylation on additional tyrosine residues.
Function Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
Protein Name Discoidin Domain-Containing Receptor 2
Discoidin Domain Receptor 2
Cd167 Antigen-Like Family Member B
Neurotrophic Tyrosine Kinase - Receptor-Related 3
Receptor Protein-Tyrosine Kinase Tkt
Tyrosine-Protein Kinase Tyro10
Cd Antigen Cd167b
Database Links Reactome: R-MMU-3000171
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Discoidin Domain-Containing Receptor 2 protein
Discoidin Domain Receptor 2 protein
Cd167 Antigen-Like Family Member B protein
Neurotrophic Tyrosine Kinase - Receptor-Related 3 protein
Receptor Protein-Tyrosine Kinase Tkt protein
Tyrosine-Protein Kinase Tyro10 protein
Cd Antigen Cd167b protein
Ddr2 protein
Ntrkr3 protein
Tkt protein
Tyro10 protein

Information sourced from Uniprot.org

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