Mouse CD141/THBD protein (Recombinant) (N-His) (STJP009792)

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STJP009792
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse CD141/THBD-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Thbd
Gene ID: 21824
Uniprot ID: TRBM_MOUSE
Immunogen Region: Gln24-Thr170
Immunogen: Mus musculus (Mouse)
Function Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway. Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition. Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation. Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response.
Protein Name Thrombomodulin
Tm
Fetomodulin
Cd Antigen Cd141
Database Links Reactome: R-MMU-140875
Reactome: -MMU-202733
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Thrombomodulin protein
Tm protein
Fetomodulin protein
Cd Antigen Cd141 protein
Thbd protein

Information sourced from Uniprot.org

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