| Function | Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program. |
| Protein Name | Interleukin-3 Receptor Subunit AlphaIl-3 Receptor Subunit AlphaIl-3r Subunit AlphaIl-3r-AlphaIl-3raInterleukin-3 Receptor Class Ii Alpha ChainCd Antigen Cd123 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinExpressed On The Cell SurfaceIsoform 2: Endomembrane SystemMostly Distributed Inside The CellsExcept In The Nuclei And Is Not Transported To The Cell Surface |
| Alternative Protein Names | Interleukin-3 Receptor Subunit Alpha proteinIl-3 Receptor Subunit Alpha proteinIl-3r Subunit Alpha proteinIl-3r-Alpha proteinIl-3ra proteinInterleukin-3 Receptor Class Ii Alpha Chain proteinCd Antigen Cd123 proteinIl3ra proteinSut-1 protein |
Information sourced from Uniprot.org
