| Host: |
HEK293 |
| Note: |
STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse CD112 (PRR2)-protein was developed from hek293. For use in research applications. |
| Conjugation: |
Unconjugated |
| Formulation: |
0.2 Mu m filtered PBS solution, pH7.2. |
| Storage Instruction: |
Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Gene Symbol: |
Nectin2 |
| Gene ID: |
19294 |
| Uniprot ID: |
NECT2_MOUSE |
| Immunogen Region: |
ECD |
| Immunogen: |
Optimized DNA sequence encoding extracellular domain of mouse nectin-2 (CD112) including a C-terminal 6His tag was expressed in HEK293 cells. NA |
| Tissue Specificity | Brain, spinal cord, spleen, kidney, heart and liver. |
| Function | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. |
| Protein Name | Nectin-2Herpes Virus Entry Mediator BHerpesvirus Entry Mediator BHvebMurine Herpes Virus Entry Protein BMhvebNectin Cell Adhesion Molecule 2Poliovirus Receptor HomologPoliovirus Receptor-Related Protein 2Cd Antigen Cd112 |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-418990Reactome: -MMU-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Nectin-2 proteinHerpes Virus Entry Mediator B proteinHerpesvirus Entry Mediator B proteinHveb proteinMurine Herpes Virus Entry Protein B proteinMhveb proteinNectin Cell Adhesion Molecule 2 proteinPoliovirus Receptor Homolog proteinPoliovirus Receptor-Related Protein 2 proteinCd Antigen Cd112 proteinNectin2 proteinMph proteinPvr proteinPvrl2 proteinPvs protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
