Mouse CD105/ENG protein (Recombinant) (N-His) (STJP009128)

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STJP009128
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse CD105/ENG-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Eng
Gene ID: 13805
Uniprot ID: EGLN_MOUSE
Immunogen Region: Asp37-Gly332
Immunogen: Mus musculus (Mouse)
Function Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis. May play a role in the binding of endothelial cells to integrins. Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3.
Protein Name Endoglin
Cell Surface Mj7/18 Antigen
Cd Antigen Cd105
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Endoglin protein
Cell Surface Mj7/18 Antigen protein
Cd Antigen Cd105 protein
Eng protein
Edg protein

Information sourced from Uniprot.org

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