| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
<1 EU/Mu g |
| Gene Symbol: |
Cd160 |
| Gene ID: |
54215 |
| Uniprot ID: |
BY55_MOUSE |
| Immunogen Region: |
Gly28-Ser160 |
| Immunogen: |
Recombinant Mouse BY55/CD160 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly28-Ser160) of mouse BY55/CD160 (Accession #NP_061237.3) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
GCIHVTSSASQKGGRLDLTC TLWHKKDEAEGLILFWCKDN PWNCSPETNLEQLRVKRDPE TDGITEKSSQLVFTIEQATP SDSGTYQCCARSQKPEIYIH GHFLSVLVTGNHTEIRQRQR SHPDFSHINGTLS |
| Function | CD160 antigen: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells. Receptor for both classical and non-classical MHC class I molecules. Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response. On activated CD4+ T cells, interacts with TNFRSF14 and down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response. In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and pro-inflammatory cytokines. CD160 antigen, soluble form: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions. |
| Protein Name | Cd160 AntigenNatural Killer Cell Receptor By55Cd Antigen Cd160 Cleaved Into - Cd160 Antigen - Soluble Form |
| Database Links | Reactome: R-MMU-198933 |
| Cellular Localisation | Cd160 Antigen: Cell MembraneLipid-AnchorGpi-AnchorCd160 AntigenSoluble Form: SecretedReleased From The Cell Membrane By Gpi Cleavage |
| Alternative Protein Names | Cd160 Antigen proteinNatural Killer Cell Receptor By55 proteinCd Antigen Cd160 Cleaved Into - Cd160 Antigen - Soluble Form proteinCd160 proteinBy55 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
