Mouse BMP-14/GDF-5 protein (Recombinant) (His-Tag) (STJP018984)

Name: Mouse BMP-14/GDF-5 protein (Recombinant) (His-Tag) (STJP018984)
SKU: STJP018984
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⇓ Datasheet ⇓ SDS Citations

SPECIFICATIONS

HostE.coli

ImmunogenMouse

STJP018984

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Short Description	Recombinant-Mouse BMP-14/GDF-5-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE/Denatured
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.5 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	Gdf5
Gene ID	14563
Uniprot ID	GDF5_MOUSE
Accession Number	NP_032135
Immunogen	Mouse
Immunogen Region	376-495aa
Immunogen Sequence	MGSSHHHHHH SSGLVPRGSH MGSAPLANRQ GKRPSKNLKA RCSRKALHVN FKDMGWDDWI IAPLEYEAFH CEGLCEFPLR SHLEPTNHAV IQTLMNSMDP ESTPPTCCVP TRLSPISILF IDSANNVVYK QYEDMVVESC GCR

Function	Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
Protein Name	Growth/Differentiation Factor 5 Gdf-5 Bone Morphogenetic Protein 14 Bmp-14
Database Links	Reactome: R-MMU-2129379
Cellular Localisation	Secreted Cell Membrane
Alternative Protein Names	Growth/Differentiation Factor 5 protein Gdf-5 protein Bone Morphogenetic Protein 14 protein Bmp-14 protein Gdf5 protein Bmp14 protein Bp protein Gdf-5 protein

Information sourced from Uniprot.org