Mouse BDNF protein (Recombinant) (N-His) (STJP009963)

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STJP009963
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse BDNF-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Bdnf
Gene ID: 12064
Uniprot ID: BDNF_MOUSE
Immunogen Region: Arg130-Arg249
Immunogen: Mus musculus (Mouse)
Post Translational Modifications Neurotrophic factor BDNF precursor form: N-glycosylated and glycosulfated, contrary to mature BDNF. Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF. Can be converted into mature BDNF by plasmin (PLG).
Function Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Neurotrophic factor BDNF precursor form: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse.
Protein Name Neurotrophic Factor Bdnf Precursor Form
Probdnf
Brain-Derived Neurotrophic Factor Cleaved Into - Neurotrophic Factor Bdnf
Database Links Reactome: R-MMU-1257604
Reactome: -MMU-6811558
Reactome: -MMU-9026527
Reactome: -MMU-9028731
Reactome: -MMU-9032759
Cellular Localisation Secreted
Neurotrophic Factor Bdnf Precursor Form: Secreted
A Proportion Of Bdnf Is Secreted As Immature Precursor (Probdnf)
Alternative Protein Names Neurotrophic Factor Bdnf Precursor Form protein
Probdnf protein
Brain-Derived Neurotrophic Factor Cleaved Into - Neurotrophic Factor Bdnf protein
Bdnf protein

Information sourced from Uniprot.org

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