Mouse ARG1 (Arginase-1) Antibody Pair (STJAP00552)

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STJAP00552-50
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Host: Rabbit/Rabbit
Applications: ELISA
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This ARG1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.
Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5.
Purification: Capture Purification: Antigen Affinity.
Detection Purification: Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Determination Method: Colormetric
Gene Symbol: Arg1
Gene ID: 11846
Uniprot ID: ARGI1_MOUSE
Immunogen: Capture immunogen: Recombinant Mouse ARG1 protien.
Detection Immunogen: Recombinant Mouse ARG1 protien.
Sample Type: Serum, plasma and other biological fluids
Function Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively.the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion. In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival. Plays a role in the immune response of alternatively activated or M2 macrophages in processes such as wound healing and tissue regeneration, immune defense against multicellular pathogens and parasites, and immune suppression and allergic inflammation.the regulatory outcome seems to be organ specific. In tumor-infiltrating dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) plays a role in suppression of T cell-mediated antitumor immunity.
Protein Name Arginase-1
Liver-Type Arginase
Type I Arginase
Database Links Reactome: R-MMU-6798695
Reactome: -MMU-70635
Cellular Localisation Cytoplasm
Cytoplasmic Granule
Alternative Antibody Pair Names Arginase-1 antibody pair
Liver-Type Arginase antibody pair
Type I Arginase antibody pair
Arg1 antibody pair

Information sourced from Uniprot.org